个人信息Personal Information
教授 博士生导师
招生学科专业:
力学 -- 【招收硕士研究生】 -- 航空学院
机械工程 -- 【招收博士、硕士研究生】 -- 航空学院
机械 -- 【招收博士、硕士研究生】 -- 航空学院
任职 : 省部级重点实验室副主任
性别:男
毕业院校:南京航空航天大学
学历:南京航空航天大学
学位:工学博士学位
所在单位:航空学院
联系方式:penghm@nuaa.edu.cn
电子邮箱:
Acoustic calculation in low frequency sonopheresis based on bubble dynamics
点击次数:
所属单位:航空学院
发表刊物:JOURNAL OF VIBROENGINEERING
关键字:acoustic sonopheresis low frequency ultrasound numerical simulation bubble dynamics
摘要:As a type of transdermal permeability enhancement, low frequency sonophoresis (LFS) has been studied for more than twenty years. The acoustic pressure in LFS is a crucial ultrasonic parameter to improve the permeability, but it is difficult to measure in the drug donor because of its small size and narrow shape. In this paper, an acoustic-piezoelectric coupling model is established based on bubble dynamics, which can be utilized to calculate the acoustic pressure distributions in LFS using a commercial finite element software called COMSOL multiphysics. The calculated results of acoustic pressure are in accordance with the measured values, so this model has great potential for theoretical analyses in acoustic fields of LFS. Calculated and experimental results show that the maximum acoustic pressure is under the transducer's head, and the value dropped as away from the head due to the acoustic attenuation caused by cavitation; the transducer head should be closer to the skin to obtain larger acoustic pressure on the skin. Therefore, this model can be used to simulate and analyze the characteristics of acoustic fields, as a theoretical tool for the structural design of the ultrasonic transducer applied in LFS.
ISSN号:1392-8716
是否译文:否
发表时间:2017-02-01
合写作者:Lu, Penghui,Zhu, Pancheng,Yu, Boping
通讯作者:彭瀚旻