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所属单位：材料科学与技术学院

发表刊物：Artif. Cells Nanomed. Biotechnol.

摘要：Radiotherapy is one of the main therapeutic methods for cancers, but radiation resistance of cancer cells still remains a serious concern. Searching for radiosensitizers to overcome such resistance is therefore urgently required. The goal of this study is to evaluate and compare the radiosensitizing efficacy of Fe3O4-OA, Ag and Fe3O4@Ag nanoparticles on U251 cells. The results show that Fe3O4@Ag nanoparticles have the highest ability of radiosensitization among the three nanoparticles. The underlying mechanism of Fe3O4@Ag nanoparticles' radiosensitivity enhancement is through decrease of the cytoprotective autophagy at the early stage, and increase of the calcium-dependent apoptosis at the later stage. These findings suggest the potential application of Fe3O4@Ag nanoparticles as a highly effective nano-radiosensitizer for the treatment of glioblastoma cells. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

ISSN号：2169-1401

是否译文：否

发表时间：2018-10-31

合写作者：Liu, Zhujun,陈峰,常树全,Miao, Yuji,Zhou, Zhuo,胡晓丹,丰俊东,张海黔

通讯作者：张晓红