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所属单位：材料科学与技术学院

发表刊物：ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY

关键字：Selenium nanoparticle radiotherapy breast cancer cells autophagy cell cycle reactive oxygen species

摘要：Radiosensitizers that increase cancer cell radio-sensitivity can enhance the effectiveness of irradiation and minimize collateral damage. Nanomaterial has been employed in conjunction with radiotherapy as radiosensitizers, due to its unique physicochemical properties. In this article, we evaluated selenium nanoparticles (Nano-Se) as a new radiosensitizer. Nano-Se was used in conjunction with irradiation on MCF-7 breast cancer cells, and efficacy and mechanisms of this combined treatment approach were evaluated. Nano-Se reinforced the toxic effects of irradiation, leading to a higher mortality rate than either treatment used alone, inducing cell cycle arrest at the G2/M phase and the activation of autophagy, and increasing both endogenous and irradiation-induced reactive oxygen species formation. These results suggest that Nano-Se can be used as an adjuvant drug to improve cancer cell sensitivity to the toxic effects of irradiation and thereby reduce damage to normal tissue nearby.

ISSN号：2169-1401

是否译文：否

发表时间：2018-01-01

合写作者：陈峰,陈峰,胡晓丹,Liu, Pei Dang,张海黔

通讯作者：Liu, Pei Dang,张海黔,张晓红