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所属单位：材料科学与技术学院

发表刊物：POLYMER CHEMISTRY

关键字：PILLARARENE-CONTAINING POLYMERS HOST-GUEST COMPLEXATION BIOMEDICAL APPLICATIONS MOLECULAR RECOGNITION DYNAMIC POLYMERS CROWN-ETHER NANOPARTICLES DELIVERY BINDING FACILE

摘要：Novel thermo-and oxidation-responsive supramolecular polymeric vesicles in water were constructed from amphiphilic supramolecular diblock copolymers at 37 degrees C via pillar[6] arene-ferrocene based host-guest interaction, in which the host polymer was pillar[6] arene-terminal-modified poly(N-isopropyl-acrylamide) (PNIPAM-P[6]) synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and the guest polymer was ferrocene-terminal-modified methoxy-poly(ethylene glycol) (mPEG-Fc). The host polymer formed micelles in water at 25 degrees C, and upon addition of guest mPEG-Fc, a hydrophilic supramolecular diblock copolymer PNIPAM-P[6] superset of mPEG-Fc was formed, which could become amphiphilic when heated to 37 degrees C and further self-assembled into supramolecular polymeric vesicles. The resulting vesicles exhibited good thermo-and oxidation-responsiveness, due to the solubility of the host polymer at different temperatures and the oxidation of the ferrocene moiety of the guest polymer, respectively. More importantly, the supramolecular polymeric vesicles could be further applied in the encapsulation of an anticancer drug (doxorubicin hydrochloride) and its controlled release in response to temperature and oxidizing agents.

ISSN号：1759-9954

是否译文：否

发表时间：2017-01-28

合写作者：Wang, Sai,Yao, Chenhao,Ni, Mengfei,Xu, Zuqiang,Cheng, Ming,Hu, Xiao-Yu,Lin, Chen,Wang, Leyong,Jia, Dianzheng

通讯作者：沈应中