所属单位：材料科学与技术学院
发表刊物：Australas. Phys. Eng. Sci. Med.
摘要：Cerenkov luminescence imaging (CLI) is an emerging optical imaging technique, which has been widely investigated for biological imaging. In this study, we proposed to integrate the CLI technique with the radionuclide treatment as a “see-and-treat” approach, and evaluated the performance of the pinhole collimator-based CLI technique. The detection of Cerenkov luminescence during radionuclide therapy was simulated using the Monte Carlo technique for breast cancer treatment as an example. Our results show that with the pinhole collimator-based configuration, the location, size and shape of the tumors can be clearly visualized on the Cerenkov luminescence images of the breast phantom. In addition, the CLI of multiple tumors can reflect the relative density of radioactivity among tumors, indicating that the intensity of Cerenkov luminescence is independent of the size and shape of a tumor. The current study has demonstrated the high-quality performance of the pinhole collimator-based CLI in breast tumor imaging for the “see-and-treat” multi-modality treatment. © 2019, Australasian College of Physical Scientists and Engineers in Medicine.
ISSN号：0158-9938
是否译文：否
发表时间：2019-06-15
合写作者：艾遥,汤晓斌,舒迪昀,龚春慧,关发达
第一作者：耿长冉
通讯作者：耿长冉