所属单位：机电学院
发表刊物：CERAMICS INTERNATIONAL
关键字：Hydroxyapatite Digital light processing Bone scaffold Biocompatibility
摘要：The bioceramic material hydroxyapatite (HA) is widely used in the field of bone repair. Based on additive manufacturing (AM) techniques, HA is fabricated with complex geometry to satisfy biomedical application requirements. Digital light processing (DLP) is a promising AM technique that is capable of producing HA parts with high accuracy and efficiency. The fabrication of HA parts using DLP is investigated in this study. Properties of the HA ceramic slurry and the process parameters of curing, debinding, and sintering are initially examined. The mechanical properties, porosity, and shrinkage of the sintered samples is then investigated. The experimental results show that ceramic samples with density above 90%, microhardness up to 270 HV, and flexural strength of 41.3 MPa can be manufactured using the DLP method. Hydroxyapatite bone scaffolds are then prepared with pore sizes of 300-600 mu m, porosity of about 49.8%, and compressive strength of 15.25 MPa, and the scaffolds are cultured with osteoblast precursor cells to detect biocompatibility. Results illustrate that the produced scaffolds possess strong biocompatibility and can promote osteoblast proliferation, adhesion, and differentiation. The HA bone scaffolds fabricated by DLP AM show strong potential to fulfill a constructive role in the medical field of human bone repair.
ISSN号：0272-8842
是否译文：否
发表时间：2019-06-01
合写作者：Liu, Zibo,Liang, Huixin,Shi, Tianshu,Xie, Deqiao,Chen, Ruoyu,Han, Xiao,Wang, Changjiang,田宗军
第一作者：沈理达
通讯作者：沈理达