Affiliation of Author(s):材料科学与技术学院
Journal:Artif. Cells Nanomed. Biotechnol.
Abstract:Radiotherapy is one of the main therapeutic methods for cancers, but radiation resistance of cancer cells still remains a serious concern. Searching for radiosensitizers to overcome such resistance is therefore urgently required. The goal of this study is to evaluate and compare the radiosensitizing efficacy of Fe3O4-OA, Ag and Fe3O4@Ag nanoparticles on U251 cells. The results show that Fe3O4@Ag nanoparticles have the highest ability of radiosensitization among the three nanoparticles. The underlying mechanism of Fe3O4@Ag nanoparticles' radiosensitivity enhancement is through decrease of the cytoprotective autophagy at the early stage, and increase of the calcium-dependent apoptosis at the later stage. These findings suggest the potential application of Fe3O4@Ag nanoparticles as a highly effective nano-radiosensitizer for the treatment of glioblastoma cells. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
ISSN No.:2169-1401
Translation or Not:no
Date of Publication:2018-10-31
Co-author:Liu, Zhujun,cf,Shuquan Chang,Miao, Yuji,Zhou, Zhuo,hxd,fjd,zhq
Correspondence Author:zxh
Date of Publication:2018-10-31