Dr. Yizhi Zhang is an associate researcher in the Department of Biomedical Engineering at Nanjing University of Aeronautics and Astronautics. She received her Ph.D. in Optical Engineering from Southeast University in 2021. She was a visiting Ph.D. scholar sponsored by the China Scholarship Council at the Basque Center for Cooperative Research in Biomaterials (CIC biomaGUNE, in Spain), under the supervision of Professor Luis Liz-Marzán. 

Her research interests focus on biophotonics and biosensors, especially surface-enhanced Raman spectroscopy (SERS) and electrochemical techniques. Recent work focuses on analyzing cellular gasotransmitters and metabolites in the course of cancers and neurological disorders. Dr. Zhang has published over 30 SCI-indexed papers. She serves as a Youth Committee Member of the Medical Biophotonics Committee of the Jiangsu Society of Biomedical Engineering.

ORCID: https://orcid.org/0000-0002-2781-195X

Publications

1. Chencheng Luo, Xiaoyu Zhu, Yizhi Zhang*, Yijun Wen, Lin Wan, Zhiyu Qian. Competitive electrochemical immunosensor for trace phosphorylated Tau181 analysis in plasma: Toward point-of-care technologies of Alzheimer’s disease. Talanta, 2025, 292, 128009.

2. Chencheng Luo, Tianyi Yang, Yizhi Zhang*, Lei Wu, Xiaoyu Zhu, Zhiyu Qian. Advancing Alzheimer’s biomarker Detection: A hairpin Aptamer-Based competitive electrochemical biosensor for trace Amyloid beta 40 analysis. Microchemical Journal, 2024, 205, 111361.

3. Yizhi Zhang#, Lei Wu#, Kuo Yang, Shenfei Zong, Zhuyuan Wang*, Yiping Cui*. 2D profiling of tumor chemotactic and molecular phenotype at single cell resolution using a SERS-microfluidic chip. Nano Research, 2022, 15(5), 4357–4365.

4. Yizhi Zhang, Idoia Gallego, Javier Plou, Jose Luis Pedraz, Luis M. Liz-Marzán, Jesus Ciriza*, Isabel García*. SERS monitoring of local pH in encapsulated therapeutic cells. Nanoscale, 2021, 13(34): 14354–14362.

5. Yizhi Zhang, Dorleta Jimenez de Aberasturi*, Malou Henriksen-Lacey, Judith Langer, Luis M. Liz-Marzán*. Live-Cell Surface-Enhanced Raman Spectroscopy Imaging of Intracellular pH: From Two Dimensions to Three Dimensions. ACS Sensors, 2020, 5(10): 3194–3206.

6. Yizhi Zhang, Zhuyuan Wang*, Lei Wu, Shenfei Zong, Binfeng Yun, Yiping Cui. Combining Multiplex SERS Nanovectors and Multivariate Analysis for In Situ Profiling of Circulating Tumor Cell Phenotype Using a Microfluidic Chip. Small, 2018, 14(20): e1704433.

Research Projects

1.National Natural Science Foundation of China (NSFC) Young Scientists Fund, Principal Investigator, 2023.01–2025.12

2.China Postdoctoral Science Foundation General Funding, Principal Investigator, 2022.11–2023.11

3.China Postdoctoral Science Foundation Special Pre-station Funding, Principal Investigator, 2021.09–2023.09

4.Nanjing Overseas Students Science and Technology Innovation Project, Principal Investigator, 2022.09–2023.09

5.NSFC Original Exploration Program, Participant, 2022.01–2024.12