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所属单位：自动化学院
发表刊物：MOLECULAR THERAPY-NUCLEIC ACIDS
关键字：LONG NONCODING RNA DOWN-REGULATION CELL-DEATH EXPRESSION GAS5 TRANSPORTERS METASTASIS CERNA LUNG PROLIFERATION
摘要：Drug resistance is a common cause of treatment failure in cancer therapy, and molecular mechanisms need further exploration. Competing endogenous RNAs (ceRNAs) can influence drug response by participating in various biological processes, including regulation of cell cycle, signal transduction, and so on. In this study, we systematically explored resistance from the perspective of ceRNA modules. First, we constructed a general ceRNA network, involving 83 long non-coding RNAs (lncRNAs) and 379 mRNAs. Next, we identified the drug resistance-related modules for 138 drugs and 19 cancer types, totaling 758 drug-cancer conditions. Function analysis showed that resistance-related biological processes were enriched in these modules, such as regulation of cell proliferation, DNA damage repair, and so on. Pan-drug and pan-cancer analyses revealed some common and specific modules across multiple drugs or cancers. In addition, we also found that drug pairs with common modules have similar structure, indicating high risk for multidrug resistance (MDR). Finally, we speculated that ceRNA pair GAS5-RPL8 could regulate drug resistance because low expression of GAS5 would enhance microRNA (miRNA)-mediated inhibition of RPL8. In total, we investigated the drug resistance by using ceRNA modules and proposed that ceRNA modules may be new markers for drug resistance that indicated a possible novel mechanism.
ISSN号：2162-2531
是否译文：否
发表时间：2019-06-07
合写作者：Liu, Haizhou,Wang, Shuyuan,Zhou, Shunheng,Meng, Qianqian,Ma, Xueyan,Wang, Lihong,姜伟
通讯作者：宋晓峰