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个人信息Personal Information
教授 博士生导师
招生学科专业：
化学 -- 【招收硕士研究生】 -- 材料科学与技术学院
材料科学与工程 -- 【招收博士、硕士研究生】 -- 材料科学与技术学院
材料与化工 -- 【招收博士、硕士研究生】 -- 材料科学与技术学院
能源动力 -- 【招收博士、硕士研究生】 -- 材料科学与技术学院
主要任职：中国化学会高级会员，中国化学会超分子专业委员会委员，江苏省化学化工学会大环与超分子专业委员会委员; “Frontiers in Chemistry”副主编；“Chinese Chemical Letters”、“Green Synthesis & Catalysis"、“RSC Advance”期刊编委
性别：女
毕业院校：中国科学院成都生物研究所
学历：中国科学院成都生物研究所
学位：理学博士学位
所在单位：材料科学与技术学院
办公地点：1号楼1401B
联系方式：18761895025
电子邮箱：
From Supramolecular Vesicles to Micelles: Controllable Construction of Tumor-Targeting Nanocarriers Based on Host?Guest Interaction between a Pillar[5]arene-Based Prodrug and a RGD-Sulfonate Guest
点击次数：
所属单位：材料科学与技术学院
发表刊物：Small
摘要：The targeting ability, drug-loading capacity, and size of the drug nanocarriers are crucial for enhancing the therapeutic index for cancer therapy. Herein, the morphology and size-controllable fabrication of supramolecular tumor-targeting nanocarriers based on host–guest recognition between a novel pillar[5]arene-based prodrug WP5-DOX and a Arg-Gly-Asp (RGD)-modified sulfonate guest RGD-SG is reported. The amphiphilic WP5-DOX⊃RGD-SG complex with a molar ratio of 5:1 self-assembles into vesicles, whereas smaller-sized micelles can be obtained by changing the molar ratio to 1:3. This represents a novel strategy of controllable construction of supramolecular nanovehicles with different sizes and morphologies based on the same host−guest interactions by using different host−guest ratios. Furthermore, in vitro and in vivo studies reveal that both these prodrug nanocarriers could selectively deliver doxorubicin to RGD receptor-overexpressing cancer cells, leading to longer blood retention time, enhanced antitumor efficacy, and reduced systematic toxicity in murine tumor model, suggesting their potential application for targeted drug delivery. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN号：1613-6810
是否译文：否
发表时间：2018-12-27
合写作者：Gao, Lei,Mosel, Stefanie,Ehlers, Martin,Zellermann, Elio,Jiang, Hao,Knauer, Shirley K.,Wang, Leyong,Schmuck, Carsten
通讯作者：胡晓玉,Mosel, Stefanie,胡晓玉