Affiliation of Author(s):材料科学与技术学院
Journal:Small
Abstract:The targeting ability, drug-loading capacity, and size of the drug nanocarriers are crucial for enhancing the therapeutic index for cancer therapy. Herein, the morphology and size-controllable fabrication of supramolecular tumor-targeting nanocarriers based on host–guest recognition between a novel pillar[5]arene-based prodrug WP5-DOX and a Arg-Gly-Asp (RGD)-modified sulfonate guest RGD-SG is reported. The amphiphilic WP5-DOX⊃RGD-SG complex with a molar ratio of 5:1 self-assembles into vesicles, whereas smaller-sized micelles can be obtained by changing the molar ratio to 1:3. This represents a novel strategy of controllable construction of supramolecular nanovehicles with different sizes and morphologies based on the same host−guest interactions by using different host−guest ratios. Furthermore, in vitro and in vivo studies reveal that both these prodrug nanocarriers could selectively deliver doxorubicin to RGD receptor-overexpressing cancer cells, leading to longer blood retention time, enhanced antitumor efficacy, and reduced systematic toxicity in murine tumor model, suggesting their potential application for targeted drug delivery. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN No.:1613-6810
Translation or Not:no
Date of Publication:2018-12-27
Co-author:Gao, Lei,Mosel, Stefanie,Ehlers, Martin,Zellermann, Elio,Jiang, Hao,Knauer, Shirley K.,Wang, Leyong,Schmuck, Carsten
Correspondence Author:胡晓玉,Mosel, Stefanie,Hu Xiaoyu
Date of Publication:2018-12-27