Prof. Yufeng Guo performed intensive studies on the interlayer interaction and mechanical behavior, mechanical-electric-chemical coupling and device principle, and structural design and performance tuning of low-dimensional materials and systems, and provides the mechanism and route to tune physical and mechanical properties of low-dimensional materials by using mechanical-electrical coupling, surface functionalization and defect engineering, and reveals the synergistic effect of substrate and ion-containing water in graphene based hydrovoltaic generators, the flexoelectricity and tribo-piezoelectricity in low-dimensional materials, the effect of defect induced structural reconstruction on the electromagnetic absorption of dielectric materials, and flexoelectricity enhanced water splitting and hydrogen evolution reaction on grain boundaries of monolayer transition metal dichalcogenides. He published over 57 SCI papers on international journals including Phys. Rev. Lett., Nano Energy, Adv. Funct. Mater., J. Phys. Chem. Lett. etc., which have already been cited over 1750 times in international journals such as Science, Nature Materials and Nature Nanotechnology. Some theoretical predictions have been confirmed by other experiments. Prof. Yufeng Guo won the second Prize of National Natural Science (the fourth place), and obtained Excellent Youth Foundation of National Natural Science Foundation of China, Distinguished Youth Foundation of National Natural Science Foundation of Jiangsu Province, and Changjiang Scholars Program of Young Scholars and New Century Excellent Talents in University of MOE.